Direct synthesis of 1,5-disubstituted-4-magnesio-1,2,3-triazoles, revisited |
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| Authors: | Krasiński Antoni Fokin Valery V Sharpless K Barry |
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| Affiliation: | Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA. kranik@scripps.edu |
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| Abstract: | After revisiting earlier works reporting the regioselective synthesis of 1,5-disubstituted-1,2,3-triazoles via the addition of bromomagnesium acetylides to azides, much improved yields of the products were obtained for a wide array of azides and alkynes. The intermediates of that reaction can be trapped with different electrophiles to regioselectively form 1,4,5-trisubstituted 1,2,3-triazoles. [reaction: see text] |
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