Total synthesis of (+/-)-galanthamine |
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| Authors: | Hu Xiang-Dong Tu Yong Qiang Zhang En Gao Shuanhu Wang Shaohua Wang Aixia Fan Chun-An Wang Min |
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| Institution: | State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou 730000, PRC. |
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| Abstract: | reaction: see text] A practical and efficient total synthesis of (+/-)-galanthamine was achieved from commercially available materials through a novel approach, in which the construction of its core structure and the special allylic alcohol group were based on a successive semipinacol rearrangement/desilyation/cyclization and Saegusa-Ito oxidation, respectively. |
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