| Design, syntheses and biological activity of novel ALS inhibitors (Ⅸ)——CoMFA of sulfonylureas and triazolopyrimidine-2-sulfonamides ALS inhibitors |
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| 引用本文： | 杨光富
,刘华银
,杨秀风
,杨华铮.Design, syntheses and biological activity of novel ALS inhibitors (Ⅸ)——CoMFA of sulfonylureas and triazolopyrimidine-2-sulfonamides ALS inhibitors[J].中国科学B辑(英文版),1999(6). |
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| 作者姓名： | 杨光富 刘华银 杨秀风 杨华铮 |
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| 作者单位： | State Key Laboratory and Institute of Elemento-Organic Chemistry，Nankai University，Tianjin 300071，China)) |
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| 基金项目： | Project supported by the National Natural Science Foundation of China (Grant No. 29832050)，the Special Key Fund of Natural Science of Tianjin (Grant No. 983801011)，the Doctoral Fund of the Education Ministry of China. |
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| 摘 要： | Quantitative structure-activity relationships for herbicidal activity against rape of sulfonylurea and triazolopyrimidin-2-sulfonamide derivatives were examined three-dimensionally using comparative molecular field analysis (CoMFA). The CoMFA results show that the slopes in steric and electrostatic fields around the molecule were significant for both series in governing the potency variations in herbicidal activity. Based upon the successful superposition between the two series, the herbicidal activity was analyzable with a single equation for the combined set of compounds, which suggested that the two different series of compounds have a common region of the receptor site.
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