A new stilbene glycoside from the n-butanol fraction of Veratrum dahuricum |
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Authors: | Li-Min Dai Jian Tang Hui-Liang Li Yun-Heng Shen Cai-Yun Peng Wei-Dong Zhang |
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Affiliation: | (1) School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, P. R. China;(2) School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200030, P. R. China;(3) Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai, 200433, P. R. China |
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Abstract: | A new stilbene glycoside, 5-methylresveratrol-3,4′-O-β-D-diglucopyranoside (1), was isolated from the n-butanol fraction of the rhizomes of Veratrum dahuricum, together with five known stilbenoids: resveratrol-3-O-β-D-glycoside (2), 4′-methylresveratrol-3-O-β-D-glycoside (3), oxyresveratrol-4′-O-β-D-glycoside (4), oxyresveratrol-3-O-β-D-glycoside (5), and oxyresveratrol-3,4′-O-β-D-diglycoside (6), and found for the first time in the investigated plant. The structures of six isolates were identified on the basis of 1D and 2D NMR data. Compounds 1–6 showed platelet aggregation inhibition, and compound 1 had an IC50 value of 383.6 μM against platelet aggregation induced by AA. Published in Khimiya Prirodnykh Soedinenii, No. 3, pp. 279–282, May–June, 2009. |
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Keywords: | Veratrum dahuricum stilbene 5-methylresveratrol-3,4′ -O-β -D-diglucopyranoside platelet aggregation |
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