Regioselective C-2 and C-6 substitution of (S)-nicotine and nicotine derivatives |
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| Authors: | Février Florence C Smith Emilie D Comins Daniel L |
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| Institution: | Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695-8204, USA. |
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| Abstract: | reaction: see text] Regioselective deprotonations of (S)-nicotine and derivatives at the C-2 and C-6 positions of the pyridine ring were performed in good to excellent yields. These methodologies allow the direct introduction of a plethora of functional groups onto the pyridine ring of nicotine. |
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