Novel Hydrophobic Biodegradable Ester-Polymers Obtained via Azlactone Chemistry |
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| Authors: | Sophia Kobauri Nino Zavaradshvili Marina Dgebuadze David Tugushi Ramaz Katsarava |
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| Affiliation: | 1. Center for Medical Polymers and Biomaterials, Georgian Technical University, 77, Kostava str., Tbilisi 0175, Georgia;2. Institute of Medical Polymeric Materials, I. Javakhishvili Tbilisi State University, 1, Chavchavadze ave., Tbilisi 0179, Georgia |
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| Abstract: | Biodegradable polymers having a potential for constructing resorbable therapeutical micro- and nano-containers were synthesized by interaction of bis-azlactones with bis-(L-leucine)-1,6-hexylene diester/1,6-diamino hexane either separately or as comonomers. The thermograms (DSC) all of them showed a wide endothermal peak within 55–120 °C with a maximum ranged from 86 °C to 96 °C. The peak was assigned to the melting of hydrophobic domains formed by aromatic terephthalic acid fragments in the polymeric backbones. Preliminary in vitro study showed that the ester-bonds containing polymers obtained are biodegradable – α-chymotrypsin catalyzed ester bonds hydrolysis rates ranged within 0.02–0.34 µmole/min. |
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| Keywords: | biodegradable bis-azlactone poly(amide/ester amide) poly(ester amide) thermal properties |
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