Swelling and thermodynamic studies of temperature responsive 2-hydroxyethyl methacrylate/itaconic acid copolymeric hydrogels prepared via gamma radiation |
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| Institution: | 1. Faculty of Technology and Metallurgy, Karnegijeva 4/V, Belgrade, Serbia;2. Laboratory for Radiation Chemistry and Physics, Vinca Institute of Nuclear Sciences, P.O. Box 522, 11001 Belgrade, Serbia, Serbia and Montenegro;1. Hungarian Academy of Sciences, Institute of Isotopes, Budapest, Hungary;2. Hungarian Academy of Sciences, Institute of Isotopes, Budapest, Hungary;1. Department of Building, Civil and Environmental Engineering, Concordia University, Montreal, Quebec, Canada H3G 1M8;2. Department of Advanced Organic Materials Science and Engineering, Kyungpook National University, Daegu 702-701, South Korea;1. CONACyT–Centro de Investigación en Química Aplicada, Av. Alianza Sur 204 Parque de Innovación e Investigación Tecnológica, Apodaca, Nuevo León 66629, Mexico;2. Centro de Química e Meio Ambiente – Instituto de Pesquisas Energéticas e Nucleares – IPEN-CNEN, Av. Professor Lineu Prestes, 2242, Cidade Universitária, 05508-000 São Paulo, SP, Brazil;1. CEA, DEN, DEC, F-13108 St. Paul Lez Durance Cedex, France;2. Institut Pprime, SP2MI, CNRS – Université de Poitiers – ENSMA, 86360 Chasseneuil, France;3. CEA, INAC, 38 054 Grenoble Cedex 9, France;4. Electricité de France (EDF), R&D Division, Les Renardières, 77818 Morez-sur-Loing, France |
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| Abstract: | The copolymeric hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) were synthesized by gamma radiation induced radical polymerization. Swelling and thermodynamic properties of PHEMA and copolymeric P(HEMA/IA) hydrogels with different IA contents (2, 3.5 and 5 mol%) were studied in a wide pH and temperature range. Initial studies of so-prepared hydrogels show interesting pH and temperature sensitivity in swelling and drug release behavior. Special attention was devoted to temperature investigations around physiological temperature (37 °C), where small changes in temperature significantly influence swelling and drug release of these hydrogels. Due to maximum swelling of hydrogels around 40 °C, the P(HEMA/IA) hydrogel containing 5 mol% of IA without and with drug-antibiotic (gentamicin) were investigated at pH 7.40 and in the temperature range 25–42 °C, in order to evaluate their potential for medical applications. |
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