Preparation of enantiomerically pure (3E)-alkyl-4-(hetero-2-yl)-2-hydroxybut-3-enoates by Candida parapsilosis ATCC 7330 mediated deracemisation and determination of the absolute configuration of (3E)-ethyl-4-(thiophene-2-yl)-2-hydroxybut-3-enoate |
| |
| Institution: | 1. Department of Chemistry, Indian Institute of Technology Madras, Chennai 600 036, India;2. Laboratory of Bioorganic Chemistry, Department of Biotechnology and National Center for Catalysis Research, Indian Institute of Technology Madras, Chennai 600 036, India |
| |
| Abstract: | Deracemisation of racemic (3E)-alkyl-4-(hetero-2-yl)-2-hydroxybut-3-enoates using Candida parapsilosis ATCC 7330 resulted in the formation of one enantiomer in high enantiomeric excess up to >99% ee] and isolated yields up to 79%]. The absolute configuration of the enantiomerically pure (3E)-ethyl-4-(thiophene-2-yl)-2-hydroxybut-3-enoate as determined by 1H NMR of the Mosher esters was found to be (S). |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
