Enantioselective addition of phenylacetylene to aldehydes catalyzed by 1,3-aminophenol ligand |
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| Institution: | 1. Graduate School of Science and Engineering, Saitama University, 255 Shimo-ohkubo, Sakura, Saitama 338-8570, Japan;2. Department of Chemical Engineering, University of Jinan, 106 Jiwei Road, Jinan, Shandong Province 250022, China |
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| Abstract: | The 1,3-aminophenol ligand (R)-1 was found to be a good catalyst for the zinc phenylacetylene addition to aldehydes. The high activity and enantioselectivity could be improved upon by basic additives. The enantioselectivity follows a linear free energy relationship with higher enantioselectivity obtained for the more reactive aryl aldehydes. |
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