Synthesis of a new chiral amino phosphine ligand and its application in the asymmetric allylic alkylation (AAA) reaction

This article describes the synthesis of a new chiral amino phosphine ligand based on an amino naphthol starting material, which is resolved efficiently by using l-tartaric acid. The asymmetric induction of the ligand in the Pd(0)-catalyzed allylic substitution of 1,3-diphenylprop-2-en-1-yl acetate with dimethyl malonate was investigated. Good yields and enantiomeric excesses up to 78% of the product were obtained.