Enzymatic resolution of α-tetralols by CALB-catalyzed acetylation |
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| Institution: | 1. Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, CEP 05508-900 S. Paulo, SP, Brazil;2. Instituto de Química de São Carlos, Universidade de São Paulo, CP 780, 13560-970 S. Carlos, SP, Brazil |
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| Abstract: | A series of homochiral α-tetralols, as well as their respective acetates, has been obtained by esterification of racemic tetralols, using Candida antarctica lipase (CALB—Novozym® 435) as the biocatalyst. This enzyme is shown to be highly efficient for the kinetic resolution of the substrates studied, affording the (+)-tetralols and the (+)-acetates in excellent enantiomeric excess (up to >99%) and very good yields (>40%). |
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