Direct asymmetric aldol reactions catalyzed by a siloxy serine organocatalyst in water |
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| Institution: | Natural Sciences and Science Education, National Institute of Education, Nanyang Technological University, Singapore 637616, Singapore |
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| Abstract: | A siloxy-l-serine organocatalyst has been developed to catalyze direct asymmetric aldol reactions in the presence of water, furnishing the β-hydroxy carbonyl scaffold in high enantio- and diastereoselectivities. The direct aldol reaction between a selection of aromatic aldehydes and cyclohexanone resulted in good yields and high enantioselectivities. |
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