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Highly diastereoselective nucleophilic addition reactions of masked acyl cyanide reagents to tert-butanesulfiminides
Affiliation:Division of Pharmaceutical Chemistry, Institute of Health Biosciences, Graduate School of The University of Tokushima, 1-78, Sho-machi, Tokushima 770-8505, Japan
Abstract:Addition reactions of dicyanomethyl tert-butyldimethylsilyl ether (H–MAC–TBS) to optically active tert-butanesulfinimides afforded α-amino acid precursors in excellent yields and with high diastereoselectivities.
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