l-Proline catalyzed direct diastereoselective aldol reactions: towards the synthesis of lyxo-(2S,3S,4S)-phytosphingosine |
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Institution: | Chemical Engineering and Process Development Division, National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India |
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Abstract: | l-Proline catalyzed direct diastereoselective aldol reactions of α-amino aldehydes with cyclic ketones have been described and utilized further for the stereoselective synthesis of the 2-amino-1,3,4-triol unit as the phytosphingosines base backbone. This leads to the formal synthesis of (2S,3S,4S)-lyxo-phytosphingosine. |
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