Enantioselective synthesis of phosphonate analogues of (R)- and (S)-homoserine

The enantioselective synthesis of (R)- and (S)-1-amino-3-hydroxypropylphosphonic acid, the phosphonate analogues of (S)- and (R)-homoserine, has been accomplished in four steps and good overall yield starting from diethyl (3R,5R)- or (3S,5S)-5-(hydroxymethyl)-2-(S)-1-phenylethyl]isoxazolidinyl-3-phosphonate, respectively.