Retention and selectivity of aromatic hydrocarbons with mono-substituted polar groups in ternary RP-HPLC systems |
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Authors: | T H Dzido H Engelhardt |
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Institution: | (1) Department of Inorganic and Analytical Chemistry, Medical Academy, Staszica 6, 20-081 Lublin, Poland;(2) Department of Applied Physical Chemistry, University of Saarland, 66041 Saarbrücken, Germany |
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Abstract: | Summary The variation in selectivity for aromatic hydrocarbons with mono-substituted polar groups is investigated in ternary mobile-phase
systems on C18 stationary phases. The dependence of log k′ on the proportions of two modifiers was determined for the solutes within the
concentration range of ternary systems obtained by mixing two binary eluents: methanol + water and tetrahydrofuran + water
or acetonitrile + water and tetrahydrofuran + water. The nature of the relationships is explained in terms of molecular shape,
molecular interactions between solute and extracted modifier and the ordering of solvated ligands on the stationary phase. |
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Keywords: | Column liquid chromatography Reversed phase systems Ternary eluents Mono-substituted aromatics Retention and selectivity |
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