ACTION SPECTRUM FOR ANTHRACENE-INDUCED PHOTOSENSITIZATION OF HUMAN SKIN |
| |
Authors: | KAYS H KAIDBEY SHIGEO NONAKA |
| |
Institution: | University of Pennsylvania School of Medicine, Department of Dermatology, Duhring Laboratories. 244 Medical Education Building/GM, 36th and Hamilton Walk, Philadelphia, PA 19104, USA |
| |
Abstract: | Abstract— The action spectrum for photosensitization by topically applied anthracene was determined in human volunteers. Spectral reactivity was demonstrated in the range between 320 and 380 nm, with peak activity at around 360 nm. Three distinct inflammatory responses viz. immediate transient erythema, delayed erythema, and wealing were evoked following exposure to effective wavelengths. The action spectra for these responses were similar but the threshold doses were different. Prior treatment with a mast cell degranulating agent (codeine) abolished anthracene-UVA induced wealing but did not influence the erythema response. These findings suggest that photosensitized damage to cutaneous mast cells may be partially responsible for some of the observed inflammatory responses, but other sites of photochemical injury are also involved. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|