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Kinetic resolution of racemic secondary alcohols via oxidation with Yarrowia lipolytica strains
Affiliation:1. BioOrganic Mass Spectrometry Laboratory (LSMBO), IPHC, Université de Strasbourg, 25 rue Becquerel, 67087 Strasbourg, France;2. IPHC, CNRS, UMR7178, 67087 Strasbourg, France;3. IECB, Université de Bordeaux, IECB, 33607 Pessac, France;4. INSERM U1212, UMR CNRS 5320, 33076 Bordeaux, France;5. CBMN, UMR 5248, CNRS, Université de Bordeaux, INP Bordeaux, 33607 Pessac, France;1. Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China;2. Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237, China;1. Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China;2. Department of Chemistry, Wuhan University, Wuhan 430072, China;3. Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources, Comprehensive Utilization, Huanggang Normal University, Huangzhou, China;1. Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia;2. University of Chemical Technology and Metallurgy, 1756 Sofia, Bulgaria;3. Institute of Science and Technology of Polymers, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain;4. Sofia University “St. Kliment Ohridski”, Faculty of Medicine, 1407 Sofia, Bulgaria;1. College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, PR China;2. State Key Laboratory of Innovative Drug and Efficient Energy-Saving Pharmaceutical Equipment, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, PR China
Abstract:Cyclic and alicyclic racemic secondary alcohols are kinetically resolved via oxidation with Yarrowia lipolytica strains. The comparison of the oxidation reactions with the reductions of the corresponding ketones supports the hypothesis of the presence of two alcohol dehydrogenases with opposite enantioselectivity.
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