Resolution of omeprazole by inclusion complexation with a chiral host BINOL |
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| Affiliation: | 1. Department of Chemical Engineering, Shandong Provincial Key Laboratory of Fine Chemicals, Qilu University of Technology, Jinan 250353, China;2. Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia;1. TU Chemnitz, Institut für Chemie, Anorganische Chemie, Straße der Nationen 62, 09111, Chemnitz, Germany;2. Department of Chemistry and Chemical Technology, Tafila Technical University, Tafila, Jordan;1. Dipartimento di Chimica e Farmacia, Università di Sassari, Via Vienna 2, 07100 Sassari, Italy;2. Dipartimento di Chimica Ciamician, Università di Bologna, Via Selmi 2, 40126 Bologna, Italy;3. Dipartimento di Chimica, Università di Ferrara, Via Luigi Borsari 46, 44100 Ferrara, Italy;1. Department of Bioorganic Chemistry, Institute of Chemistry and Food Technology, Faculty of Engineering and Economics, Wrocław University of Economics, Komandorska 118/120, 53-345 Wrocław, Poland;2. Institute of Low Temperature and Structure Research, Polish Academy of Sciences, Okólna 2, 50-422 Wrocław, Poland;3. Faculty of Agriculture at Azzaytuna University, Azzaytuna, Libya |
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| Abstract: | Both (S)-(−)- and (R)-(+)-enantiomers of omeprazole were directly resolved by inclusion complexation with a chiral host compound (S)-(−)- or (R)-(+)-2,2′-dihydroxy-1,1′-binaphthyl in high enantiomeric excess (>99% e.e.). |
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