Stereospecific synthesis of differentially protected (2S,4S)-2,4-diaminoglutaric acid suitable for incorporation into peptides |
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| Institution: | 1. Chemical Laboratory, CSIR-Central Leather Research Institute, Sardar Patel road, Adyar, Chennai 600020, India;2. Biological material Laboratory, CSIR-Central Leather Research Institute, Sardar Patel road, Adyar, Chennai 600020, India;1. Singapore University of Technology and Design, 487372, Singapore;2. Center for Solar Photovoltaics Materials & Technology (CPV), Surya University, Tangerang 15810, Indonesia;3. Buddhi Dharma University, Tangerang 15115, Indonesia;4. Advanced Light Source (ALS), Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA 94720, United States;5. SunPower Corporation, R&D, San Jose, CA 95134, U.S.A. |
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| Abstract: | The first synthesis of differentially protected (2S,4S)-2,4-diaminoglutaric acids 2 and 3 suitable for incorporation into peptides has been accomplished in a completely stereospecific manner in seven steps (overall yield 25–28%) from tert-butyl (2S,4S)-4-azido-N-tert-butoxycarbonylprolinate 5. |
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