Chiral ligands with pyridine donors in transition metal catalyzed enantioselective cyclopropanation and hydrosilylation reactions |
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| Institution: | 1. Dipartimento di Chimica, Università di Sassari, via Vienna 2, I-07100 Sassari, Italy;2. Institut für Anorganische Chemie der Universität Regensburg, D-93040 Regensburg, Germany;1. GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, United Kingdom;2. Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, NJ 07065, USA;3. Northumbria University, Department of Applied Sciences, Faculty of Health and Life Sciences, Newcastle upon Tyne NE1 8ST, United Kingdom;1. Department of Applied Chemistry, Faculty of Engineering, Osaka Institute of Technology, 5-16-1 Omiya, Asahi-ku, Osaka 535-8585, Japan;2. Division of Applied Chemistry, Graduate School of Engineering, Osaka Institute of Technology 5-16-1 Omiya, Asahi-ku, Osaka 535-8585, Japan;3. Nanomaterials Microdevices Research Center, Osaka Institute of Technology, 5-16-1 Omiya, Asahi-ku, Osaka 535-8585, Japan;1. Servicio de Medicina Interna, Corporación Sanitaria y Universitaria Parc Tauli, Instituto Universitario Parc Taulí, Sabadell (Barcelona), España;2. Servicio de Laboratorio de Inmunología, UDIAT, Corporación Sanitaria y Universitaria Parc Taulí, Instituto Universitario Parc Taulí, Universidad Autónoma de Barcelona (UAB), Sabadell (Barcelona), España;3. Servicio de Hepatología, Corporación Sanitaria y Universitaria Parc Taulí, Instituto Universitario Parc Taulí, Universidad Autónoma de Barcelona (UAB), Sabadell (Barcelona), España;4. Servicio de Medicina Interna, Hospital Universitario Vall d’Hebrón, Barcelona, España;5. Unidad de Estadística, Fundación Parc Taulí, Corporación Sanitaria y Universitaria Parc Taulí, Instituto Universitario Parc Taulí, Universidad Autónoma de Barcelona (UAB), Sabadell (Barcelona), España;1. B. Verkin Institute for Low Temperature Physics and Engineering, National Academy of Sciences of Ukraine, 47 Lenin Ave., 61103 Kharkov, Ukraine;2. V. Lashkaryov Institute of Semiconductor Physics, National Academy of Sciences of Ukraine, 41 Nayki Ave., 03028 Kyiv, Ukraine;1. G. K. Boreskov Institute of Catalysis, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russian Federation;2. Novosibirsk State University, 630090 Novosibirsk, Russian Federation |
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| Abstract: | Copper(I) and rhodium(I) complexes prepared in situ from Cu(OTf)(C6H6)0.5] and Rh(cod)Cl]2 with a range of chiral 2,2′-bipyridines, 5,6-dihydro-1,10-phenanthrolines, 1,10-phenanthrolines and 2,2′:6′,2′′-terpyridines were assessed as chiral catalysts for the enantioselective cyclopropanation of styrene with diazoacetates and for the hydrosilylation of acetophenone with diphenylsilane. Enantioselectivities up to 68% in the cyclopropanation and up to 32% in the hydrosilylation were obtained. |
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