DPAMPP in catalytic asymmetric reactions: enantioselective synthesis of l-homophenylalanine |
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| Affiliation: | 1. Department of Chemistry, Faculty of Science, Dicle University, 21280 Diyarbakır, Turkey;2. Science and Technology Application and Research Center (SIUBTAM), Siirt University, 56000 Siirt, Turkey |
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| Abstract: | l-Homophenylalanine 1, a key intermediate of most commercially important ACE inhibitors, was prepared via catalytic asymmetric hydrogenation of (Z)-2-acetamido-4-phenylcrotonate 3a with a cationic rhodium complex of (1R,2S)-DPAMPP, followed by acid-hydrolysis of the protecting groups in good yield with >99.9% enantioselectivity. |
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