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Lipase-catalyzed resolution of 2-fluorodecanoic acid
Affiliation:1. Department of Physical Chemistry, University of Debrecen, Debrecen, P.O. Box 400, H‐4002, Hungary;2. MTA-DE Redox and Homogeneous Catalytic Reaction Mechanisms Research Group, Debrecen, P.O. Box 400, H-4002, Hungary;3. Institute for Solid State Physics and Optics, Wigner Research Centre for Physics, Hungarian Academy of Sciences, Konkoly Thege Miklós u. 29-33, H-1121, Budapest, Hungary;1. School of Pharmaceutical Sciences, Nanjing Tech University, No.30 South Puzhu Road, Pukou District, 211816, Nanjing, PR China;2. College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, No.30 South Puzhu Road, Pukou District, 211816, Nanjing, PR China;3. College of Food Science and Light Industry, Nanjing Tech University, No.30 South Puzhu Road, Pukou District, 211816, Nanjing, PR China;4. Jiangsu National Synergetic Innovation Center for Advanced Materials, 30 Puzhunan Road, Nanjing 211816, Jiangsu, PR China;1. Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, PO Box 173, Lucknow 226031, Uttar Pradesh, India;2. Academy of Scientific and Innovative Research, New Delhi, India
Abstract:Kinetic resolutions of alkyl (±)-2-fluorodecanoates by lipase-catalyzed hydrolysis and of (±)-2-fluorodecanoic acid by lipase-catalyzed esterification are described for the first time.
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