Asymmetric oxidation of 1,3-cyclohexadiene catalysed by chloroperoxidase from Caldariomyces fumago |
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| Institution: | 1. College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450008, PR China;2. Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, PR China;3. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China;4. Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, PR China |
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| Abstract: | Chloroperoxidase from Caldariomyces fumago catalyses the oxidation of prochiral 1,3-cyclohexadiene using TBHP as terminal oxidant. The process occurs enantioselectively and furnishes the non-racemic trans diols 1,2- and 1,4-dihydroxycyclohexene, (−)-3 and (+)-4, in good ee and yield. |
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