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Diversity oriented synthesis of pyran based polyfunctional stereogenic macrocyles and their conformational studies
Authors:Arya Ajay  Shrikant Sharma  Munna Prasad Gupt  Vikas Bajpai   Hamidullah  Brijesh Kumar  Mahabir Prasad Kaushik  Rituraj Konwar  Ravi Sankar Ampapathi  Rama Pati Tripathi
Affiliation:Medicinal and Process Chemistry Division, Sophisticated Analytical Instrumentation Facility, Endocrinology Division, CSIR-Central Drug Research Institute , Lucknow-226001, U.P., India, and Process Technology Division, Defence and Research Development Establishment , Jhansi Road, Gwalior-474011, M. P., India.
Abstract:A new approach to synthesize a homologous series of 14-, 15-, and 16-membered drug-like, macrocyclic glycoconjugates involving TBAHS promoted azide-propenone intramolecular cycloaddition in designed C-glycopyranosyl butenones from a simple sugar d-glucose and d-mannose is reported.
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