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Diversity oriented synthesis of pyran based polyfunctional stereogenic macrocyles and their conformational studies |
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| Authors: | Arya Ajay Shrikant Sharma Munna Prasad Gupt Vikas Bajpai Hamidullah Brijesh Kumar Mahabir Prasad Kaushik Rituraj Konwar Ravi Sankar Ampapathi Rama Pati Tripathi |
| Institution: | Medicinal and Process Chemistry Division, Sophisticated Analytical Instrumentation Facility, Endocrinology Division, CSIR-Central Drug Research Institute , Lucknow-226001, U.P., India, and Process Technology Division, Defence and Research Development Establishment , Jhansi Road, Gwalior-474011, M. P., India. |
| Abstract: | A new approach to synthesize a homologous series of 14-, 15-, and 16-membered drug-like, macrocyclic glycoconjugates involving TBAHS promoted azide-propenone intramolecular cycloaddition in designed C-glycopyranosyl butenones from a simple sugar d-glucose and d-mannose is reported. |
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