Enzymatic sculpting of nanoscale and microscale surface topographies |
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| Authors: | Jen-Huang Huang Arul Jayaraman Victor M Ugaz |
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| Institution: | Artie McFerrin Department of Chemical Engineering, Texas A&M University, 3122 TAMU, College Station, TX 77843 (USA). |
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| Abstract: | Lithography-free etching of complex surface features is achieved by harnessing the enzyme proteinase K (PK), controlled by bovine serum albumin (BSA), to digest a biodegradable polymer. This bio-sculpting process is used to construct a membraneless filtration device for the size-based isolation and enrichment of cells from whole blood. |
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| Keywords: | biomaterials enzymes microfluidics nanofabrication patterning |
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