Liposome-based delivery of biological drugs |
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Authors: | Kosheli Thapa Magar George Frimpong Boafo Xiaotong Li Zhongjian Chen Wei He |
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Affiliation: | 1. Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China;2. Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China |
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Abstract: | Biological drugs are attracting tremendous attention in disease treatment. However, their application is significantly limited by their inherent properties, such as high hydrophilicity, poor membrane-permeability, low stability, and larger size. Liposome-based drug delivery systems are emerging as promising tools to improve their delivery, owing to their ability to reduce toxicity, improve bioavailability, and enhance the therapeutic efficacy of the drug by optimizing delivery to the specific target site. Here, we reviewed the types of liposomes and their applications as carriers for biological drugs to treat various diseases, emphasized the commercial products, and ultimately provided perspectives in this field. |
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