| Diketopyrrolopyrrole-derived organic small molecular dyes for tumor phototheranostics |
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| 作者姓名： | Qianli Ma Xu Sun Weili Wang Dongliang Yang Cangjie Yang Qian Shen Jinjun Shao |
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| 作者单位： | 1. Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (Nanjing Tech);2. Department of Chemistry, Boston College, Chestnut Hill |
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| 基金项目： | supported by the National Natural Science Foundation of China (No. 21972067)；;the Natural Science Foundation of Jiangsu Province (Nos. BK20200092 and BK20200710)； |
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| 摘 要： | Cancer is one of the leading causes of human death around the world. Phototherapy, including photodynamic therapy(PDT) and photothermal therapy(PTT), is an emerging light-triggered cancer treatment and shows the advantages of non-invasiveness and low side effects. The design and preparation of efficient phototherapeutic agents are of great significance for phototherapy. Diketopyrrolopyrrole(DPP) is a small molecular organic dye featuring outstanding photophysical properties, facile tuning of str...
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| 收稿时间： | 23 July 2021 |
Diketopyrrolopyrrole‐derived organic small molecular dyes for tumor phototheranostics |
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| Qianli Ma,Xu Sun,Weili Wang,Dongliang Yang,Cangjie Yang,Qian Shen,Jinjun Shao.Diketopyrrolopyrrole-derived organic small molecular dyes for tumor phototheranostics[J].Chinese Chemical Letters,2022,33(4):1681-1692. |
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| Institution: | 1. Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing 211800, China;2. Department of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467, United States |
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| Abstract: | Cancer is one of the leading causes of human death around the world. Phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), is an emerging light-triggered cancer treatment and shows the advantages of non-invasiveness and low side effects. The design and preparation of efficient phototherapeutic agents are of great significance for phototherapy. Diketopyrrolopyrrole (DPP) is a small molecular organic dye featuring outstanding photophysical properties, facile tuning of structures and properties, and excellent photostability; thus, phototherapeutic agents based on organic small molecular DPP derivatives have attracted significant research attention for not only phototherapy but also photodiagnosis of fluorescence imaging (FLI) and photoacoustic imaging (PAI). This review summarizes the recent progress of various DPP-based organic small molecules on phototheranostics during the last five years. The molecular structure design and their phototheranostics performances are discussed in detail, as will be of great help for further creation of DPP-based phototheranostics. |
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