4-Hydroxy-2-quinolones. 92. Reaction of 1-R-4-chloro-3-ethoxycarbonyl-2-oxo-1,2-dihydroquinolines with anilines |
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| Authors: | I V Ukrainets L V Sidorenko O V Gorokhova N A Jaradat |
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| Institution: | (1) National Pharmaceutical University, Kharkov, 61002, Ukraine;(2) An-Najah National University College of Pharmacy, P.O. Box 7, Nablus, Palestine |
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| Abstract: | A preparative method is proposed and the synthesis of 4-arylamino-2-oxo-1,2-dihydroquinolines has been effected. An X-ray
structural investigation of 4-(4-chlorophenylamino)-2-oxo-1-propyl-1,2-dihydroquinoline-3-carboxylic acid has been carried
out enabling the ease of decarboxylating such compounds to be substantiated. Results are given of a study of the anti-inflammatory
activity of the synthesized compounds.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 386–395, March, 2006. |
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| Keywords: | 4-arylamino-2-oxo-1 2-dihydroquinolines decarboxylation anti-inflammatory activity X-ray structural analysis |
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