Facile and efficient synthesis of 1-[2-(6,7-dimethyl-3,4-dihydronaphthalen-2-yl)ethyl]pyrrolidine hydrochloride |
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| Authors: | Jiann-Jyh Huang Mou-Yung Yeh Fung Fuh Wong |
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| Affiliation: | (1) Development Center for Biotechnology, No. 101, Lane 169, Kangning St., Xizhi City, Taipei County, Taiwan, 221, China;(2) Department of Chemistry, National Cheng Kung University, No. 1, Ta Hsueh Rd., Tainan, Taiwan, 70101, China;(3) Nan Jeon Institute of Technology, No. 178, Chaocin Rd., Yanshuei Township, Tainan County, 737, Taiwan, China;(4) Environmental Resource Management Research Center, National Cheng Kung University, No. 500, Sec. 3, An-ming Rd., Tainan City, Taiwan, 709, China |
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| Abstract: | An efficient and facile procedure for the preparation of 1-[2-(6,7-dimethyl-3,4-dihydronaphthalen-2-yl)ethyl]pyrrolidine hydrochloride from 6,7-dimethyl-1,2,3,4-tetrahydronaphtalen-1-one in four steps is proposed. It includes one-step synthesis of 1-(6,7-dimethyl-1,2,3,4-tetrahydronaphthalen-2-yl)acetic acid as key intermediate and subsequent transformations of functional groups therein. Published in Russian in Zhurnal Organicheskoi Khimii, 2008, Vol. 44, No. 3, pp. 449–453. The text was submitted by the authors in English. |
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