Synthesis of a lignan skeleton via nickel- and palladium-phosphine complex catalyzed grignard coupling reaction of halothiophenes |
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Authors: | Akio Minato Kohei Tamao Keizo Suzuki Makoto Kumada |
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Institution: | Department of Synthetic Chemistry, Kyoto University, Yoshida, Kyoto 606 and Kyoto College of Pharmacy, Yamashina, Kyoto 607, Japan |
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Abstract: | A lignan skeleton is prepared in good yield through desulfurization of 3,4-dibenzyl-thiophene or 2,5-diaryl-3,4-dimethylthiophenes which are obtained by the nickel- or palladium-phosphine complex catalyzed Grignard cross-coupling reaction of halothiophenes. |
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