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A novel synthesis of the carbapen-2-em ring system |
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| Authors: | RW Ratcliffe TN Salzmann BG Christensen |
| Institution: | Merck Sharp & Dohme Research Laboratories, Box 2000, Rahway, N.J. 07065 U.S.A. |
| Abstract: | A new synthesis of the carbapenem ring system, as found in thienamycin and related natural products, has been developed. The key step involves a highly efficient carbene insertion reaction which produces the bicyclic ring system by forming the N3 bond. |
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