Parviflorine,a glycosidic spirobenzylisoquinoline alkaloid

(+)-Parviflorine ($\text{1}$), found in $\text{Fumaria parviflora}$ Lam. (Fumariaceae), is the first known glycosidic spirobenzylisoquinoline alkaloid. Its acid hydrolysis yields (+)-parfumine ($\text{4}$) and D-glucose. Klyne's rule indicates that $\text{1}$ is a β-D-glucoside. The absolute configuration shown in expressions $\text{1-11}$ is predominant among spirobenzylisoquinolines. A generalization has been drawn between plant source and the oxygenation pattern of ring C for the spirobenzylisoquinoline alkaloids.