Nuclear analogs of β-lactam antibiotics. 7. The synthesis of 3-thia- and 3-aza-1-dethiaceph-1-em esters

The total synthesis of a 3-thia- and a 3-aza-1-dethiacepham ($\text{9}$ and $\text{16}$) are described. Neither compound possessed antibacterial activity $\text{vs}$$\text{B}$. $\text{subtilis}$. An unsaturated analog, a 3-aza-1-dethiaceph-1-em exhibited weak antibacterial activity.