Studies on phosphonic acid antibiotics. I. Structure and synthesis of 3-(n-acetyl-n-hydroxyamino)propylphosphonic acid (FR-900098) and its n-formyl analogue (FR-31564)期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Studies on phosphonic acid antibiotics. I. Structure and synthesis of 3-(n-acetyl-n-hydroxyamino)propylphosphonic acid (FR-900098) and its n-formyl analogue (FR-31564)

Authors:	Takashi Kamiya Keiji Hemmi Hidekazu Takeno Masashi Hashimoto

Affiliation:	Research Laboratories, Fujisawa Pharmaceutical Co., Ltd. 2-1-6, Kashima, Yodogawa-ku, Osaka 532, Japan

Abstract:	The structure elucidation of FR-900098 ( $1$ ) isolated from a microorganism source and the syntheses of FR-900098 and its N-formyl analogue, FR-31564 ( $2$ ), are described. The latter possesses a superior antimicrobial activity.

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