Studies on phosphonic acid antibiotics. II. Synthesis of 3-(n-acetyl-n-hydroxyamino)-2(r)-hydroxypropylphosphonic acid (FR-33289) and 3-(n-formyl-n-hydroxyamino)-1-<span class="math"><math><mtext>trans</mtext></math></span>-propenylphosphonic acid (FR-32863)期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Studies on phosphonic acid antibiotics. II. Synthesis of 3-(n-acetyl-n-hydroxyamino)-2(r)-hydroxypropylphosphonic acid (FR-33289) and 3-(n-formyl-n-hydroxyamino)-1- $trans$ -propenylphosphonic acid (FR-32863)

Authors:	Masashi Hashimoto Keiji Hemmi Hidekazu Takeno Takashi Kamiya

Affiliation:	Research Laboratories, Fujisawa Pharmaceutical Co., Ltd. 2-1,6, Kashima, Yodogawa-ku, Osaka 532, Japan

Abstract:	The syntheses of FR-33289 ( $3$ ), originally isolated from a microorganism, and FR-32863 ( $6$ ), first designed on the basis of a biogenetic consideration and recently found to be also present in nature, are described.

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