| STUDIES ON DNA SEQUENCE SPECIFIC BINDING PROTEINS FOR 5'''' FLANKING UPSTREAM REGION OF CPSI GENE |
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| 引用本文： | 洪焰,王智,李士谔. STUDIES ON DNA SEQUENCE SPECIFIC BINDING PROTEINS FOR 5'''' FLANKING UPSTREAM REGION OF CPSI GENE[J]. 中国科学B辑(英文版), 1991, 0(2) |
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| 作者姓名： | 洪焰 王智 李士谔 |
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| 作者单位： | Institute of Basic Medical Sciences，Chinese Academy of Medical Sciences，Institute of Basic Medical Sciences，Chinese Academy of Medical Sciences，Institute of Basic Medical Sciences，Chinese Academy of Medical Sciences Beijing 100730，PRC，Beijing 100730，PRC，Beijing 100730，PRC |
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| 基金项目： | Project supported by the National Natural Science Foundation of China. |
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| 摘 要： | Two specific carbamyl phosphate synthetase Ⅰ gene binding nuclear proteins (M. W. 109kD and 74 kD) have been determined in the rat liver by the protein blotting technique (South-western blot assay). The result shows that they are not present in the normal rat spleenand F-26 rat hepatoma cell. The Ba131 nuclease deletion in the CPSI gene 5' upstream regionproves that the binding sites for 109 kD and 74 kD are respectively located in the regions of- 38 bp to - 4 bp and - 113 bp to -38 bp. The binding proteins may be the liver-specific onesof the CPSI gene, which are related to hepatocyte differentiation and hepatocarcinogenesis.
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STUDIES ON DNA SEQUENCE SPECIFIC BINDING PROTEINS FOR 5'''' FLANKING UPSTREAM REGION OF CPSI GENE |
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| HONG YAN,WANG ZHI,LI SHI-E Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences,Beijing ,PRC. STUDIES ON DNA SEQUENCE SPECIFIC BINDING PROTEINS FOR 5'''' FLANKING UPSTREAM REGION OF CPSI GENE[J]. Science in China(Chemistry), 1991, 0(2) |
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| Authors: | HONG YAN WANG ZHI LI SHI-E Institute of Basic Medical Sciences Chinese Academy of Medical Sciences Beijing PRC |
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| Affiliation: | HONG YAN,WANG ZHI,LI SHI-E Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences,Beijing 100730,PRC |
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