New HPLC-chiral stationary phases for enantiomeric resolution of sulfoxides and selenoxides |
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| Authors: | G. Gargaro F. Gasparrini D. Misiti G. Palmieri M. Pierini C. Villani |
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| Affiliation: | (1) Istituto di Chimica Organica, Facoltà di Farmacia, Università degli Studi “La Sapienza”, P. le A. Moro 5, 00185 Roma, Italy;(2) Dipartimento di Scienze Chimiche, Università degli Studi, Via S. Agostino 1, 62032 Camerino, Italy |
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| Abstract: | Summary Enantiomers of several sulfoxides and some selenoxides can be easily separated by using a new chiral stationary phase (CSP-DACH-DNB) containing the 3,5-dinitrobenzoyl derivative of R,R-(-)1,2-diamino-cyclohexane as selector, covalently bonded to the siliceous matrix. The easy operative conditions and the high enantioselectivity values (α) allow a direct transfer of the analytical separations to a semi-preparative and preparative scale. |
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| Keywords: | Column liquid chromatography Optical resolution of sulfoxides and selenoxides Chiral bonded phases |
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