Synthesis and biological evaluation of ebselen and its acyclic derivatives |
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| Authors: | Chang Tsu-Chung Huang Mei-Lan Hsu Wen-Lin Hwang Jing-Min Hsu Ling-Yih |
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| Institution: | Department of Biochemistry, National Defense Medical Center, Neihu, Taipei, Taiwan, ROC. |
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| Abstract: | Five ebselen and three acyclic ebselen derivatives were synthesized. These compounds were screened for their glutathione peroxidase (GSH Px)-like activity and scavenging activity against 1,1-diphenyl-2-pycryl-hydrazyl (DPPH) and peroxynitrite radical. All tested compounds displayed similar significant GSH Px-like activity, which are slightly higher than that of ebselen. The peroxynitrite scavenging activity showed that the acyclic allylseleno 4c was five times more potent than ebselen. |
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