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Delay equation formulation of a cyclin-structured cell population model
Authors:Ricardo Borges  Àngel Calsina  Sílvia Cuadrado  Odo Diekmann
Affiliation:1. Departament de Matemàtiques, Universitat Autònoma de Barcelona, 08193, Bellaterra (Barcelona), Spain
2. Department of Mathematics, Utrecht University, Utrecht, The Netherlands
Abstract:The aim of this paper is to derive a system of two renewal equations from individual-level assumptions concerning a cyclin-structured cell population. Nonlinearity arises from the assumption that the rate at which quiescent cells become proliferating is determined by feedback. In fact, we assume that this rate is a nonlinear function of a weighted population size. We characterize steady states and establish the validity of the principle of linearized stability.
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