On the influence of the resonance and inductive effects on the hydrophobicity of the isomeric methylquinolones analyzed by means of RP-HPLC |
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| Authors: | A. Siwek J. Sliwiok |
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| Affiliation: | (1) Institute of Chemistry, Silesian University, 9, Szkolna Street, 40006 Katowice, Poland |
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| Abstract: | Summary Hydrophobicity of methylquinolines was compared with their retention data measured on two stationary phases by reversed-phase HPLC, and with the experimental partition coefficients (log P). The influence of the substituent position on the hydrophobicity is discussed and a two-parameter correlation equation is proposed permitting the prediction of the log k values with help of the inductive and resonance effects. |
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| Keywords: | Column liquid chromatography Inductive effects Resonance effects Methylquinoline derivatives |
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