Unconventional nucleotide analogues. 3. 4-(N1-pyrimidyl)-2-aminobutyric acids |
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| Authors: | A J H Nollet and U K Pandit |
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| Institution: | Laboratory of Oiganic Chemistry, University of Amsterdam, Nieuwe Achtergracht 129, Amsterdam, The Netherlands |
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| Abstract: | Alkylation of 4-ethoxy-2-hydroxypyrimidines (10a, b), via their anions, provides a convenient procedure for preparing N1-substituted derivatives. Reaction of 10a, b with t-butyl 4-bromo-2-benzyloxycarbamidobutyrate (17) gives good yields of the N1-alkylated products 18a, b. The latter have been converted to uracil- (20a), thymine- (20b) and cytosine- (21) substituted  -aminobutyric acids. |
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