Aryliodine (III) Diacetates as Substrates for Pd-Ag Catalyzed Arylation of Alkenes |
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Authors: | Evdokimov Nikolai M Kornienko Alexander Magedov Igor V |
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Institution: | Department of Chemistry, New Mexico Institute of Mining and Technology, Socorro, NM 87801, United States |
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Abstract: | An unprecedented application of aryliodine(III) diacetates as substrates in Pd-Ag catalyzed arylation of alkenes is described. The mechanistic studies revealed that the binary Pd-Ag catalysis leads to the decomposition of aryliodine(III) diacetates to oxygen and aryl iodides followed by arylation of alkenes forming Heck-type products. Under optimized conditions both electron-rich and electron-deficient alkenes undergo arylation in high yields. Advantageously, the reaction proceeds smoothly in water as a solvent and neither organic ligands nor inert atmosphere are required. |
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Keywords: | Synthesis in water Palladium Cross-coupling Hypervalent iodine |
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