Selective 1,2-dihalogenation and oxy-1,1-dihalogenation of alkynes by N-halosuccinimides |
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Authors: | Jinhua LiuWenjuan Li Chao WangYao Li Zhiping Li |
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Affiliation: | Department of Chemistry, Renmin University of China, Beijing 100872, China |
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Abstract: | 1,2-Dihalogenation and oxy-1,1-dihalogenation of alkynes by N-halosuccinimides can be selectively realized through using different reaction conditions. α,β-Dihalo alkenes were obtained exclusively using THF as solvent without using any catalyst, while α,α-dihalo ketones were synthesized using a mixed solvent of THF and H2O in the presence of FeCl3·6H2O. Terminal aromatic alkynes are smoothly transformed into α,α-dihalo ketones on water without a catalyst. |
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