Epoxytwinol A, a novel unique angiogenesis inhibitor with C2 symmetry, produced by a fungus |
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| Authors: | Kakeya Hideaki Onose Rie Koshino Hiroyuki Osada Hiroyuki |
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| Institution: | Antibiotics Laboratory, Discovery Research Institute, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan. hkakeya@riken.jp |
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| Abstract: | We isolated a novel unique pentaketide dimer designated as epoxytwinol A from the fermentation broth of a fungus. The structure of epoxytwinol A was determined to have a new carbon skeleton with C(2) symmetry by elucidation of spectroscopic evidence. Epoxytwinol A inhibited endothelial cell migration stimulated by vascular endothelial growth factor (ED(100)= 2.6 microM). |
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