| 呋喃碳苷衍生物的合成及主产物构型的确认 |
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| 引用本文： | 侯莉莉,孔军,赵方利,严琳. 呋喃碳苷衍生物的合成及主产物构型的确认[J]. 化学研究, 2009, 20(2) |
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| 作者姓名： | 侯莉莉 孔军 赵方利 严琳 |
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| 作者单位： | 河南大学,药学院,河南,开封,475004;河南大学,学生处,河南,开封,475001 |
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| 摘 要： | 在三氯氧磷催化下将2-甲基-5-(2′-氯-2′-脱氧-D-半乳糖-1-丁醇基)-3-乙酰基呋喃经脱水反应得到呋喃碳苷衍生物(2-甲基-5-[(4′-α-羟基-3′-β-氯)-2′-四氢呋喃基]-3-乙酰基呋喃),并对反应机理进行了讨论.通过2D NMR图谱确认了主产物的构型为α构型.
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| 关 键 词： | 呋喃 碳苷 半乳糖 结构表征 |
Synthesis of Furan C-Glycoside Derivative and Confirmation of Absolute Configuration of the Main Product |
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| HOU Li-li,KONG Jun,ZHAO Fang-li,YAN Lin. Synthesis of Furan C-Glycoside Derivative and Confirmation of Absolute Configuration of the Main Product[J]. Chemical Research, 2009, 20(2) |
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| Authors: | HOU Li-li KONG Jun ZHAO Fang-li YAN Lin |
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| Abstract: | The furan C-glycoside derivative,3-acetyl-5-[(3′-β-chloro-4′-α-hydroxyl)-2′-tetrahydrofuryl]-2-methyl furan,was synthesized by using 3-acetyl-5-(2′-chloro-2′-deoxy-D-galacto-tetritol-1-yl)-2-methyl furan as building block under acid condition.The mechanism and the determination of α-configuration of the main isomer were expatiated. |
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| Keywords: | furan C-glycoside galactose structure characterization |
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