Total synthesis of dendrobate alkaloid (+)-241D, isosolenopsin and isosolenopsin A: application of a gold-catalyzed cyclization |
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| Authors: | Gouault Nicolas Le Roch Myriam Pinto Gisele de Campos David Michèle |
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| Affiliation: | Equipe PNSCM, UMR 6226, Université de Rennes 1, 2 avenue du Pr Léon Bernard, 35043 Rennes, France. nicolas.gouault@univ-rennes1.fr |
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| Abstract: | A new approach to total syntheses of piperidine alkaloids (+)-241D, isosolenopsin and isosolenopsin A has been developed from D-alanine. The key step to access the chiral pyridinone intermediate was achieved via a gold mediated cyclization. Finally, various reduction conditions afforded the natural products in few steps and good overall yields. |
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