The regioselectivity of the ring opening of 1-activated or nonactivated 2-alkoxycarbonyl or 2-cyanoaziridines by carbanions of the dicarbonyl compounds |
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Authors: | Zoheir Bouayad Josette Chanet-Ray S Ducher Roger Vessire |
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Institution: | Zoheir Bouayad,Josette Chanet-Ray,S. Ducher,Roger Vessière |
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Abstract: | Ring opening of title compounds with alkyl malonates, acetylacetone, methyl acetylacetate, and malononitrile was studied. The regioselectivity of the opening depends on several factors. A phenyl group on C? 3 favours C? 3? N bond cleavage, whereas C? 2? N bond cleavage is predominant with C? 3-substituted or C? 2? H aziridines. Cyanoaziridines are predominantly cleaved at C? 3? N. The aziridine configuration at C? 2 and C? 3 is maintained during the cyclisation in pyrrolidones. |
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