Synthesis of 3,5-disubstituted 1,2,4-triazoles containing trimethoxyphenyl groups: Potential antagonists of platelet activating factor

In an effort to develop a new class of Platelet Activating Factor antagonists, 3,5-disubstituted 1,2,4-triazoles containing trimethoxyphenyl groups have been synthesized. The synthesis of symmetrical triazoles 5 and 6 , as well as two methods of synthesizing unsymmetrical triazole 7 , are reported.